Frances Tiafoe will face Lorenzo Musetti in the quarterfinals of the French Open. Betting on Tiafoe to win at least one set (covering the +2.5 sets handicap) appears to be a prudent choice, considering his recent form, head-to-head record, and performance trends.

Tiafoe has reached his first Roland Garros quarterfinal without dropping a set, defeating opponents such as Pablo Carreño Busta and Daniel Altmaier. This marks a significant milestone, as he becomes the first American to reach the French Open quarterfinals without losing a set since Andre Agassi in 1995 . Musetti, seeded eighth, has also shown strong form, advancing with victories over players like Holger Rune, though he has dropped sets in his recent matches.

In their head-to-head encounters, Tiafoe leads 4–3 overall, including a 3–2 advantage on the main tour . While Musetti has won two of their three meetings on clay, Tiafoe's overall success against him suggests he can secure at least one set in this match.

Tiafoe's aggressive baseline play and powerful serve have been effective throughout the tournament. His ability to hold serve consistently and apply pressure during return games increases the likelihood of him winning a set. Musetti's recent matches, which have extended to four sets, indicate that he can be challenged, especially by a player of Tiafoe's caliber.

Considering Tiafoe's flawless performance thus far, his favorable head-to-head record against Musetti, and his capacity to compete at a high level, betting on him to cover the +2.5 sets handicap is a well-founded decision. His current trajectory suggests he is well-equipped to challenge Musetti and potentially advance further in the tournament.

Best odds available at PaddyPower.